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Vitamin B6 (pyridoxine and pyridoxal 5'-phosphate) - Monograph
(PDF)
Alternative Medicine Review 2001 (Feb); 6 (1): 87–92 ~ FULL TEXT
Researchers have found a direct correlation between carpal tunnel syndrome (CTS) and a deficiency in P5P, and that treatment with 100–200 mg pyridoxine daily for at least 12 weeks was highly beneficial in reducing both the symptomology and a P5P deficiency associated with CTS. [14–16] A few studies have shown no clinical benefit from pyridoxine HCl supplementation, [17–19] with most of the reports of beneficial effects coming from Ellis et al. [15, 20–23] A 1996 literature review of clinical trials using pyridoxine to treat CTS concluded that the evidence for the use of pyridoxine as the sole treatment
for CTS is weak, but that it may be valuable as an adjunctive treatment through its effect on altered perception of pain and increased pain threshold. [24]
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