FROM:
European Spine Journal 2018 (Sep); 27 (Suppl 6): 776-785 ~ FULL TEXT
Scott Haldeman, Margareta Nordin, Roger Chou, Pierre Côté,
5Eric L. Hurwitz, Claire D. Johnson, Kristi Randhawa, et. al.
Department of Epidemiology,
School of Public Health,
University of California Los Angeles,
Los Angeles, CA, USA.
PURPOSE: Spinal disorders, including back and neck pain, are major causes of disability, economic hardship, and morbidity, especially in underserved communities and low- and middle-income countries. Currently, there is no model of care to address this issue. This paper provides an overview of the papers from the Global Spine Care Initiative (GSCI), which was convened to develop an evidence-based, practical, and sustainable, spinal healthcare model for communities around the world with various levels of resources.
METHODS: Leading spine clinicians and scientists around the world were invited to participate. The interprofessional, international team consisted of 68 members from 24 countries, representing most disciplines that study or care for patients with spinal symptoms, including family physicians, spine surgeons, rheumatologists, chiropractors, physical therapists, epidemiologists, research methodologists, and other stakeholders.
RESULTS: Literature reviews on the burden of spinal disorders and six categories of evidence-based interventions for spinal disorders (assessment, public health, psychosocial, noninvasive, invasive, and the management of osteoporosis) were completed. In addition, participants developed a stratification system for surgical intervention, a classification system for spinal disorders, an evidence-based care pathway, and lists of resources and recommendations to implement the GSCI model of care.
CONCLUSION: The GSCI proposes an evidence-based model that is consistent with recent calls for action to reduce the global burden of spinal disorders. The model requires testing to determine feasibility. If it proves to be implementable, this model holds great promise to reduce the tremendous global burden of spinal disorders. These slides can be retrieved under Electronic Supplementary Material.
KEYWORDS: Back pain; Global burden of disease; Neck pain; Quality of health care; Spinal diseases
From the FULL TEXT Article:
Introduction
Spinal disorders are a major cause of disability, economic
hardship, and morbidity in high-income communities and
are of increasing concern in low- and middle-income communities. [1, 2] With an aging worldwide population, the
burden of spinal pain is projected to continue to increase. [3]
The available data suggest that the burden of spinal disorders
is at least as great in low- and middle-income countries as
in high-income countries. [4] Disability and costs attributed
to spinal pain are projected to increase in coming decades,
especially in resource-challenged countries, where health
and other systems are often fragile and not equipped to cope
with this growing burden. [5] This has led to increasing calls
to action to address this burden. Leaders in the spinal care
community emphasize that, when considering care of spinal
disorders in low- and middle-income countries, it is essential
to prevent the use of practices that are ineffective, harmful,
or wasteful. [6] Fragmented and outdated models of care
have failed to address widespread misconceptions, held
by health professionals and the lay public alike, about the
causes, prognosis, and effectiveness of the many treatments
for spinal pain. [6]
World Spine Care was established in 2008 with the realization
that current models of care in high-income countries
should not be reproduced in low- and middle-income countries
or in communities with limited resources in high-income
countries. World Spine Care is a nonprofit organization with
the mission to improve lives in underserved communities by
providing sustainable, integrated, and evidence-based spine
care. World Spine Care has initiated spinal programs in Botswana,
the Dominican Republic, India, and Ghana. These programs
are supported by government agencies, university volunteer
clinical services, and community education programs
and are integrated into existing healthcare systems. [7] Each of
these countries has different levels of resources, cultures, and
expectations. These few small programs, although providing
care to their communities, were not meeting the World Spine
Care’s greater vision of “a world in which everyone has access
to the highest quality spine care possible.” This vision requires:
(1) a low-cost and efficient model of care, (2) consistency with
the current evidence, (3) the ability to be taught to providers
with different levels of education, and (4) the capacity to be
integrated into healthcare programs anywhere in the world,
especially in underserved communities and low- and middleincome
countries.
To work toward this vision, World Spine Care convened the
Global Spine Care Initiative (GSCI) to develop an evidenceinformed,
practical, and sustainable, spinal healthcare model for
communities around the world with various levels of resources.
Funding was obtained from the Skoll Foundation and the
NCMIC Foundation. The Skoll Foundation grant was a matching
grant. To receive the grant, the members of the GSCI participated
without any remuneration beyond travel expenses. This satisfied
the requirement for the matching grant. In 2015, contracts were
signed with the University of Ontario Institute of Technology/
Canadian Memorial Chiropractic College Centre for the Study of
Disability Prevention and Rehabilitation to carry out the literature
searches and administrative functions for the GSCI.
Based on experience from World Spine Care programs,
patients seeking care from clinicians and community clinics
in low-income settings are likely to present with a wide scope
of spine-related concerns. These patients have a high incidence
of chronic symptoms that interfere with functional ability. In
the absence of local secondary medical care, serious systemic
diseases (i.e., spinal infections and developmental or congenital
spinal deformities) are more commonly seen at a primary
care setting in low-income communities than in high-income
communities. [7]
rovide care consistent with current evidence-based spine
guidelines are scarce or absent in low- and middle-income
communities. To be successful, a model of care should be
practical, relevant, and sufficiently simple to be implementable
by clinicians with limited training in the care of spinal disorders.
At the same time, it should avoid ineffective or harmful
treatments or diagnostic procedures that have the potential to
waste limited resources.
The primary goal of the GSCI was to develop an evidencebased
model of care for the management of spine-related
disorders that could be implemented anywhere in the world.
The secondary goal was to gather and synthesize information
about the most effective assessment, preventive, and therapeutic
approaches so that underserved communities with limited
resources may benefit from this knowledge.
Methods
The methodology used by the GSCI is described in the
summary and in each of the papers. [8–21] Fifteen papers
were developed to address the goals of this initiative.
Nine papers are foundational. These papers informed the
four consensus-based papers that provide detail for the
classification, care pathway, resource requirements, and
model of care. Requests to participate in the GSCI were
sent to leading spine clinicians and scientists around the
world. The final interprofessional, international team that
contributed to the GSCI consisted of 68 members from
24 countries and included members of most healthcare
professions and specialties that study or care for patients
with spinal symptoms, including family physicians, spine
surgeons, rheumatologists, chiropractors, physical therapists,
epidemiologists, research methodologists, and other
stakeholders.
Results: summary of foundational papers
Review of the global and community impact of spinal disorders
Global burden
[18]: A literature review summarized
relevant findings and trends related to back and neck
pain from studies on the global burden of disease. This
review revealed that in 1990, low back pain and neck
pain were ranked as the 12th leading cause of disabilityadjusted
life years globally; in 2005, they rose to be the
eighth leading cause, and in 2015, they rose higher to
the fourth leading cause, just below ischemic heart disease,
cerebrovascular disease, and lower respiratory tract
infections. In 2015, over half a billion people worldwide
had low back pain and more than a third of a billion had
neck pain lasting more than 3 months duration. Low
back pain and neck pain are the leading causes of years
lived with disability in most countries and in most agegroups.
Community burden
[14]: The primary targets for the
GSCI were underserved communities and low- and
middle-income countries. For this reason, a systematic
review of the individual and community-based burden of
spinal disorders in rural communities in low- and middle-
income communities was completed. The literature
primarily focused on low back pain. The prevalence of
low back pain appears greater among females, in those
with less education, the presence of specific psychological
factors (stress, anxiety, depression), and in alcohol
consumers. Estimates of neck pain prevalence were
lower than those of back pain in both rural and urban
areas, but the precise magnitude of these differences
is uncertain due to the small number of studies and
large variability in estimates. Similar to low back pain,
neck pain was also greater in females. These findings
are consistent with a recent systematic review focusing
on chronic pain in low- and middle-income countries,
which showed an overall prevalence of low back pain of
21% in the general population and a higher prevalence in
the elderly (28%) and in workers (52%). The conclusion
from this review was that the prevalence of and disability
associated with low back and neck pain is enormous,
has increased over the past 25 years, is increasing more
rapidly in communities with limited resources, and will
likely exact an increasing toll with population aging.
Evidence-based interventions to address spinal disorders
Assessment
[17]: In summary, clinicians should: take a
clinical history and determine the presence of pathological,
psychological, and social flags; perform a physical
examination (musculoskeletal and neurological); not
routinely obtain diagnostic imaging for spinal pain without
pathological flags; and obtain diagnostic imaging
and laboratory testing when severe and progressive neurological
deficits are present and when serious pathologies
are suspected.
Noninvasive management
[19]: In summary, clinicians
should provide education and reassurance, advise
patients with spinal pain to remain active, and provide
information about self-care options. For acute
spinal disorders without serious pathology, clinicians
should consider the primary evidence-based treatment
options: superficial heat, exercise, manual therapy, and
nonsteroidal anti-inflammatory drugs (NSAIDs). For
patients with chronic spinal disorders without serious
pathology, primary treatment options are exercise, yoga,
cognitive behavioral therapy, acupuncture, biofeedback,
progressive relaxation, massage, manual therapy, interdisciplinary
rehabilitation, NSAIDs, acetaminophen,
and antidepressants. For patients with spinal pain with
radiculopathy, clinicians may consider NSAIDs, exercise,
or spinal manipulation. The use of other interventions
requires extrapolation from evidence regarding
effectiveness for non-radicular spinal pain. It was felt to
be reasonable to consider guidelines developed for highresource
settings adaptable for use in low-income communities.
Decision determinants should be influenced
by factors such as costs, availability of interventions,
cultural and patient preferences, benefits, harms, and the
quality of underlying evidence.
Invasive interventions
[21]]: Elective surgery and
interventional procedures have limited availability in
low- and middle-income communities due to a lack of
resources and trained surgeons. It is necessary for surgical
and invasive interventional procedures to be prioritized
within these settings. Lower priority surgical
interventions include fusion for lumbar/non-radicular
neck pain. Higher priority surgical interventions include
discectomy and decompressive surgery for cervical or
lumbar radiculopathy, cervical myelopathy, and lumbar
spinal stenosis.
Surgical care stratification
[15]: A survey of surgeons
from multiple countries was undertaken to provide information
on the feasibility of surgery in different settings.
This study resulted in a stratification scheme for surgical
care of spinal disorders that could serve as a guide for
improved resource utilization in low-income communities.
The five-level surgical care stratification identified
diagnostic and therapeutic procedures that can be safely
and effectively performed at each level.
Noninvasive management of acute spinal compression
fractures
[16]: The literature on compression fractures
due to osteoporosis was reviewed to provide an example
of a systemic disease with spinal symptoms. The review
noted that conservative management of acute pain and
recovery of function in adults with compression fractures
should include calcitonin for analgesic-refractory
acute pain, a spinal orthosis for pain relief, early mobilization,
and exercise.
Psychological and social issues
[20]: A literature review
of the psychological and social factors that are strong
predictors of outcomes for people with back pain was
completed. For acute low back pain, intervention options
include: reassurance and education of patients; investigation
and discussion of irrational or maladaptive
beliefs; identification of psychological and social yellow
flags; and referral for psychological evaluation in
the absence of improvement at 4 weeks. When a patient
is present in the subacute phase, the goal of intervention
selection is to prevent chronicity, and to identify patients
at risk through careful medical and psychological evaluation.
Other treatment goals during the acute and subacute
phases include: improving function; removing or
modifying psychological or social barriers to recovery
through active supervised exercises, possibly cognitive
and behavioral evaluation; and multidisciplinary rehabilitation
if available. Clinicians need to engage patients
when establishing treatment goals and negotiating a
treatment plan. Clinicians need to use careful listening,
reassurance, and information to help meet patients’ perceived
needs.
Prevention and public health
[8, 22]: This study found
41 risk factors and 39 comorbidities related to 12 common
spine-related disorders. The high incidence of these
factors demonstrated that spinal disorders are not isolated
health concerns but are complex biopsychosocial
components of health. Clinicians should assess and track
individuals for risk factors and comorbidities associated
with spinal concerns and intervene if necessary. A range
of possible interventions to reduce the impact of spinal
disorders include: prevention of the first occurrence
of a spine-related disorder, preventing worsening of a
spine condition that has already occurred, and reducing
the disability of an ongoing spinal disorder. Prevention
interventions should be targeted at modifiable risk factors
and comorbidities found during the patient assessment.
Clinicians who are providing care for a patient
presenting with spine-related symptoms should educate
individuals on how to reduce risks and manage any
associated comorbidities. Clinicians should recommend
how individuals and caregivers may act autonomously
to prevent or decrease future severity and disability. It is
important for clinicians to refer or co-manage patients
with advanced or comorbid conditions to prevent worsening
of a spinal disorder. Clinicians should be involved
in community spinal health programs by collecting community
and population health information about spinerelated
risk factors and comorbidities and by participating
in or reinforcing community education programs
aimed at preventing or reducing the burden of spinal
disorders.
Summary of GSCI classification, care pathway, resources, and model of care papers
Classification of spinal disorders
[9]: Categorization
of individuals who present with spinal concerns into
classes can assist with more efficient and effective triage,
clinical decision making, and management. A review
of the literature identified ten classification systems for
spinal disorders. However, none satisfied the criteria
that they could be used in a comprehensive interventionbased
spine care pathway. Therefore, a GSCI classification
system of spinal disorders was developed which
incorporated the principles of and would be consistent
with existing classification systems. The six components
of the GSCI classification system include: no or
minimal symptoms (class 0); mild symptoms but minimal
interference with activities (class I); moderate or
severe symptoms with interference of activities (class
II); spine-related neurological symptoms or signs (class
III); severe bony deformity, trauma or pathology (class
IV); and spine-related symptoms, destructive lesions
related to systemic pathology, or other non-related spinal
pathology (class V). Subclasses include chronicity,
severity, and other factors to allow for different interventions
or recommendations. If a person has multiple
complaints, each spinal region is classified separately.
The GSCI classification can accommodate all spinal
disorders and was developed to link to the care pathway.
Care pathway
[11]: A care pathway links evidence-based
interventions to the presenting symptoms and pathology,
as described in the GSCI classification system. This process
ensures that interventions are appropriate and that
people receive the necessary care while at the same time
reducing the cost and morbidity of excessive or inappropriate
interventions. The GSCI care pathway was created
to be simple, adaptable to clinicians with different levels
of training and skills, and implementable in communities
with limited resources. The GSCI care pathway has
five decision steps: (1) awareness, (2) initial triage, (3)
provider assessment, (4) intervention, and (5) outcomes.
The pathway was developed to guide the management
of patients after their concern has been classified. The
care pathway was written to be sufficiently simple so it
could be included as a prompt or in the development of
educational tools such as pocket or flashcards, a wall
chart, or in electronic media. This has the potential of
facilitating the education of clinicians with limited experience
or training in the management of spinal disorders
and helping guide interprofessional communication
between providers of spinal care. The proposed steps in
the pathway are person-centered, evidence-based and
can be integrated into a continuum of services.
Resources
[13]: It is necessary to identify resources that
are essential to the implementation of a care pathway;
thus, a framework of resources was developed to match
the care pathway. The resource list was structured to
start with the least invasive interventions self-care and
community-based prevention programs followed by primary
spine care, secondary spine care, and tertiary spine
care. The resources, education, skills, and competencies
necessary to provide population-based spine care,
primary spine care, secondary spine care, and tertiary
spine care as noted in the care pathway at each of these
levels were then described. The checklist of resources
was organized into the following categories: healthcare
provider knowledge and skills, materials and equipment,
human resources, facilities, and infrastructure. The list
identifies resources needed to implement a spine care
program in any community based upon community
needs.
Model of Care and Implementation
[12]: The GSCI
model of care includes eight core principles: personcentered,
people-centered, biopsychosocial, proactive,
evidence-based practices, integrative, collaborative, and
self-sustaining. These principles were included in the
model of care and a series of steps to implement the
model. The model of care has six proposed action steps.
Step 1: Project initiation and initial preparations:
The decision to implement a spine care program
begins when an individual or community recognizes
a need, such as when a government agency,
employer, clinic, or organization recognizes an
endemic spinal problem they wish to address. This
step includes the assessment of whether stakeholders
in the community and decision leaders are
interested and able to establish a spine care program.
Step 2: Assessment of the current situation: Assessment
includes evaluation of the current healthcare
system (e.g., infrastructure, resources, funding,
processes, and personnel). The assessment should
identify the needs and resources of a community. As
each healthcare system is unique, the infrastructure,
resources, workforce, and processes must be evaluated
at each location to determine what is available
and what needs to be further developed or obtained
in order to implement a spine care program.
Step 3: Planning and designing solutions: An
implementation plan should be developed based on
information from the assessment step. Preparations
should be made to implement the model, including
training or recruiting healthcare providers who can
apply the care pathway. Resources are then identified
and secured.
Step 4: Implementation: Once the plan has been
approved by stakeholders, a pilot implementation
step should be considered to test the system and to
demonstrate effectiveness and feasibility. This initial
implementation step should build confidence and
inform the planners and stakeholders as to whether
the system is ready for larger scale implementation.
Once implementation has been shown to be feasible,
the implementation plan commences. Each location
is unique. Therefore, successful implementation
requires flexibility.
Step 5: Assessment and evaluation: After implementation,
assessment outcomes are evaluated to identify
areas of potential improvement, to see whether
program goals are being met, to identify what course
corrections are needed, and whether any new goals
need to be introduced. Key performance indicators
are evaluated at regular intervals and used to inform
the direction of change.
Sustain program and scale up: Once it is
determined that the program has achieved its goals,
it should be sustained. The program should be monitored
to ensure that support, resources, communications,
and ongoing training will continue. Once
the program has demonstrated success at a local
level, scaling up should be considered to include
larger communities, all levels of care, and even to a
national level.
Discussion
The GSCI has completed the steps necessary to recommend
a classification system, a care pathway, required resources,
and implementation recommendations for a spine model of
care. These steps have been developed by an interprofessional,
international panel of scientists and clinicians. The
proposed model of care can be considered by any government,
private entity, or clinician in any setting irrespective of
the available resources, with the goal of reducing the burden
of spinal disorders in their communities.
The GSCI aims to ensure people get the right care, at
the right time, by the right team, and in the right place. For
an individual in the community presenting with a spinerelated
concern, the care pathway allows for symptoms to
be described in terms of spine location, severity, chronicity,
interference with activities, the presence of neurological
deficits, serious trauma or deformity, and red flags suggesting
serious systemic disease. This presentation is linked
to current evidence for assessment and management (i.e.,
noninvasive, invasive, psychological, and complex medical
or surgical interventions) as described in the care pathway.
This model proposes a new approach to spinal disorders,
and we believe that this is the first attempt to suggest a
comprehensive care pathway for underserved communities
and low- and middle-income countries. This model satisfies
WHO criteria for integrated people-centered health
services by putting the comprehensive needs of individuals
and communities at the center of the healthcare system and
empowers people to take an active role in their health. It
also satisfies the criteria set out by WHO in its “Framework
for Action on Interprofessional Education & Collaborative
Practice” in that it presents a means of educating clinicians
in the principles of evidence-based spinal care that is not
specific to any healthcare profession and can easily be taught
and utilized. [23]
This proposed GSCI model answers a call to action
made by an international panel of low back pain authorities. [6] Although we cannot claim that the proposed model of
care is the only solution, our recommendations attempt to
address many of the problems that were presented in the call
for action [5]. The GSCI recommendations are consistent
with the proposed approach to low back pain in this call for
action. The recommendations rely on current evidence that
should guide practice [24] and focusses on the importance of
public health policy, self-care, and education of the general
population. They also take into account patient and clinician
concerns, prevention strategies, and expectation from interventions. [6] However, based on our experience at the World
Spine Care programs, it is insufficient for a model to focus
only on low back pain. To properly address spine-related
disorders, all spinal regions must be considered, including
the upper back and neck. A functional model must also go
beyond only pain and include other spine-related conditions,
especially since there is a higher incidence of untreated serious
pathology that presents to spine care clinicians in underserved
communities. [1, 2]
Conclusion
The GSCI proposes an evidence-based model that is consistent
with recent calls for action to reduce the global burden of
spinal disorders. The GSCI offers a framework to implement
an evidence-based model of spine care. Each component of
this model needs to be tested. Further research, especially
in underserved communities and low- and middle-income
countries, should be a priority if the global burden of spinal
disorders is to be addressed. The GSCI model requires testing
in clinical settings with different resources to determine
feasibility and whether it has the desired impact on the burden
of spinal disorders in these communities. If the GSCI
model of care proves to be implementable and effective, it
holds promise in addressing and reducing the tremendous
global burden of spinal disorders.
Funding
The Global Spine Care Initiative and this study were funded by grants from the Skoll Foundation and NCMIC Foundation. World Spine Care provided financial management for this project. The funders had no role in study design, analysis, or preparation of this paper.
Conflict of interest
Spine Care. Clinical Policy Advisory Board and stockholder, Palladian Health. Advisory Board, SpineHealth.com. Book Royalties, McGraw Hill. Travel expense reimbursement—CMCC Board. MN declares funding from Skoll Foundation and NCMIC Foundation through World Spine Care; Co-Chair, World Spine Care Research Committee. Palladian Health, Clinical Policy Advisory Board member. Book Royalties Wolters Kluwer and Springer. Honoraria for speaking at research method courses. RC declares funding from AHRQ to conduct systematic reviews on treatments for low back pain within last 2 years and honoraria for speaking at numerous meetings of professional societies and nonprofit groups on topics related to low back pain (no industry sponsored talks). PC is funded by a Canada Research Chair in Disability Prevention and Rehabilitation at the University of Ontario Institute of Technology and declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. Canadian Institutes of Health Research Canada. Research Chair Ontario Ministry of Finance. Financial Services Commission of Ontario. Ontario Trillium Foundation, ELIB Mitac. Fond de Recherche and Sante du Quebec. EH declares he is a consultant for: RAND Corporation; EBSCO Information Services; Southern California University of Health Sciences; Western University of Health Sciences Data and Safety Monitoring Committee, chair, Palmer Center for Chiropractic Research, research committee co-chair, World Spine Care. CDJ is president of Brighthall Inc; she is an NCMIC Board of Director; however, neither she nor NCMIC board makes funding decisions for the NCMIC Foundation; the views in this article are those of the authors and not those of Stanford University, Stanford Health Care, or Qualcomm. KR declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. BNG receives speaker fees and travel reimbursement from NCMIC Speakers’ Bureau; he is secretary of Brighthall Inc; the views in this article are those of the authors and not those of Stanford University, Stanford Health Care, or Qualcomm. DKG declares travel expenses: CMCC to present at the WSC Spine Conference in Botswana. EAc declares grants: Depuy Synthes Spine, Medtronic; Speaker’s bureau: AOSpine, Zimmer Biomet. AA declares no COI. EA declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. TB declares European Spine Journal provided a grant to investigate scoliosis. OB declares he is a consultant for: Pacira Pharmaceuticals, Inc., Palladian Health; travel expenses: World Spine Care; and stipend: World Spine Care. PB declares contribution to salary for Global Musculoskeletal Alliance (G-MUSC), the Bone and Joint Decade work. JMC declares funding from Spanish Government Grant ESPY 112/18. SE is an employee of the Botswana Ministry of Health and Wellness. CG declares travel expenses: Palmer College to GSCI meetings; is consultant: American Chiropractic Association, Spine IQ, Healthwise, Quality Insights of Pennsylvania, RAND Co., Prezacor, Inc. (Stock Options); PCORI (board member); and grants from Collaborative Care for Veterans with Spine pain and Mental Health Issues. NIH/Kiernan Chiropractic Care in Rehabilitation at Crotched Mountain: Crotched Mountain Private Sector Integrated Chiropractic Study N/A. NCMIC Foundation Chiropractic services, Assessment of Chiropractic Treatment for Low Back Pain; RAND Subcontract, Department of Defense Prime Award #W81XWH-11-2-017 Sub #9920110071. JH declares his research group has extensive funding from Danish public funding agencies, the European Union, and Danish charities. MH declares travel support from World Spine Care. JM declares general research resources from USF Research Center and research grants from funding agencies: FEMA, US Department of Homeland Security (EMW-2013-FP-00723); Palladian Health Advisory board: Clinical Policy and Advisory Board; Intellectual property rights: inventor of Web-based system to deliver exercise (Employer—USF: copyright holder). TM declares fellowship grant-Medtronics. JM is a WSC Board Member. EM declares AO Spine Africa Faculty courses—honorarium. GO declares he is a consultant and receives travel support as clinic director, World Spine Care. HR declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. MS declares he is a scientific advisor, NuSpine; consultant, and State Farm. ES declares funding from Ba?kent University Research Fund. ATV declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. LV declares funding to UOIT from Skoll Foundation and NCMIC Foundation through World Spine Care. WW declares Palladian Health Clinical Policy Advisory Board member. JJW declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. HY declares funding to UOIT from Skoll Foundation, NCMIC Foundation through World Spine Care. Remaining authors declare that they have no conflict of interest.
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European Spine Journal 2018 (Sep); 27 (Suppl 6): 823–837
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The Global Spine Care Initiative: A Summary of Guidelines on
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This is the third of 4 articles in the remarkable
Lancet Series on Low Back Pain
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