Table 1.
Genetic polymorphisms associated with hypertension
Gene Polymorphisms Association with HT Reference TH rs6356, rs10770141, (TCAT)n Sympathetic function, blood pressure 68 BDKRB2 -58C>T, rs1799722 Baroreflex sensitivity in never-treated hypertensive patients 76 GNB3 825C>T, 1429C>T, 5177G>A Increased intracellular signal transduction, essential hypertension 72 ADRB2 Arg16Gly, Gln27Glu Arterial blood pressure 72 ADRA1A Arg347Cys Essential hypertension 72 SLC6A2 rs168924 Essential hypertension 72 GNAS 393T>C, FokI(+/-) Hypertension through dysfunctions of the ANS 74 AGT M235T Interaction with the ANS in the regulation of blood pressure and cardiovascular function 50 AGTR1 A1166C Interaction with the ANS in the regulation of blood pressure and cardiovascular function 50 AGTR2 A1675G Interaction with the ANS in the regulation of blood pressure and cardiovascular function 50 TRPV1 rs222747 Contribution to BP differences during static exercise 12 GCH1 +243C>T Diastolic and systolic blood pressure 73 DBH -970C>T, -1021C>T, -2073C>T Essential hypertension 69 PNMT rs876493, rs3764351 Blood pressure regulation 71 COMT -1187G>C, rs4680 Essential hypertension 72