Levels of Reduced and Oxidized Coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine
in the CSF of Patients with Alzheimer's Disease Demonstrate That
Mitochondrial Oxidative Damage and/or Oxidative DNA Damage
Contributes to the Neurodegenerative Process

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:    Frankp@chiro.org

FROM:   J Neurol 2010 (Mar); 257 (3): 399-404

Isobe C, Abe T, Terayama Y

Department of Neurology,
Iwate Medical University,
19-1 Uchimaru, Morioka,
Iwate, 020-0805, Japan,
chiso@apost.plala.or.jp

---

To investigate the possibility that mitochondrial oxidative damage, oxidative DNA damage or both contribute to the neurodegenerative process of Alzheimer's disease (AD), we employed high-performance liquid chromatography using an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q-10 (CoQ-10) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 30 patients with AD and in 30 age-matched controls with no neurological disease. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF of the AD group (78.2 +/- 18.8%) was significantly higher than in the control group (41.3 +/- 10.4%) (P < 0.0001). The concentration of 8-OHdG in the CSF of AD patients was greater than in the CSF of controls (P < 0.0001) and was positively correlated with the duration of illness (r (s) = 0.95, P < 0.0001). The %CoQ-10 was correlated with concentrations of 8-OHdG in the CSF of AD patients (r (s) = 0.66, P < 0.001). The present study suggests that both mitochondrial oxidative damage and oxidative DNA damage play important roles in the pathogenesis of early AD development.

Return to Co-Q10

Since 10-11-2009