Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway

doi:10.3390/ijms19010268

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Int J Mol Sci. 2018 Jan; 19(1): 268.

Published online 2018 Jan 16. doi: 10.3390/ijms19010268

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Effect of glyceollins on cognitive function in Nrf2 wild-type mice. Nrf2 wild-type C57BL/6 mice (five weeks old, n = 9–15) were pretreated with glyceollins (10 mg/kg bw) 24 h before cognitive function or behavior tests, and then subjected to Y-maze (A); passive avoidance (B); and Morris Water maze (C) tests after injected i.p. with scopolamine (1 mg/kg bw). Values are mean ± SD (n = 9–15). Different alphabetical letters (a, b, c) indicate statistically significant differences.