Table 2
Effects of Supplemental CoQ10 Intake on IL-6
| Meta-Analysis Authors and Date | Number of Studies in Meta-Analysis | Number of Participants in Meta-Analysis | Median CoQ10 (intake/d) | Median Duration (wk) | Main Findings of Meta-Analysis (pg/mL) | Q TestP Value | I2 Statistic% | Egger or Begg Test P Value | Quality Assessment and Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Farsi et al 201913 | 10 | 454 | 200 mg | 12 | ↓ 0.37, P < .05 | .01 | 57 | NS | 3/10 high Cochrane |
| Jorat et al 201914 | 3 | 129 CAD | 150 mg | 12 | ↓ 1.63, P < .01 | .000 | 95 | NS | 3/3 high Cochrane |
| Mazidi et al 201716 | 7 | 385 | 200 mg | 12 | ↓ 0.72, P < .001 | NS | 52 | NS | 5/7 high Cochrane |
| Fan et al 201717 | 8 | 402 | 200 mg | 12 | ↓ 1.61, P = .002 | .000 | 83 | NS | 5/8 high Jadad |
| Zhai et al 201718 | 4 | 182 | 200 mg | 12 | ↓ 0.89, NS | NS | 84 | NS | 3/4 high Cochrane |
CAD, coronary artery disease;
CoQ10, coenzyme Q10;
IL-6, interleukin 6;
NR, not reported;
NS, not significant