Table 3
Effects of Supplemental CoQ10 Intake on TNF-α
| Meta-Analysis Authors and Date | Number of Studies in Meta-Analysis | Number of Participants in Meta-Analysis | Median CoQ10 (intake/d) | Median Duration (wk) | Main Findings of Meta-Analysis (pg/mL) | Q Test P Value | I2 Statistic % | Egger or Begg Test P Value | Quality Assessment and Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Farsi et al 201913 | 8 | 348 | 200 mg | 12 | ↓ 0.44, P < .05 | .004 | 66 | NS | 3/8 high Cochrane |
| Jorat et al 201914 | 3 | 102 CAD | 150 mg | 12 | ↑ 0.22, NS | .000 | 90 | NS | 3/3 high Cochrane |
| Fan et al 201717 | 7 | 277 | 100 mg | 12 | ↓ 0.49, P = .027 | .015 | 65 | NS | 4/7 high Jadad |
| Zhai et al 201718 | 3 | 125 | 300 mg | 12 | ↓ 0.45, P < .0001 | NS | 0 | NS | 2/3 high Cochrane |
CAD, coronary artery disease;
CoQ10, coenzyme Q10;
NR, not reported;
NS, not significant;
TNF-α, tumor necrosis factor alpha.