Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study

doi:10.1371/journal.pone.0147565

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PLoS One. 2016; 11(2): e0147565.

Published online 2016 Feb 3. doi: 10.1371/journal.pone.0147565

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Table 3

Association of OW, HT, DL and IGT in cervical, thoracic and lumbar region, respectively.

		Cervical		Thoracic		Lumbar
		OR (95%CI)	p-value	OR (95%CI)	p-value	OR (95%CI)	p-value
Overweight	Yes vs no	1.28 (0.92–1.78)	0.1397	1.75 (1.24–2.51) ^*	0.0016	1.87 (1.06–3.48) ^*	0.0306
Hypertension	Yes vs no	1.19 (0.85–1.66)	0.286	1.54 (1.09–2.18) ^*	0.0138	0.88 (0.52–1.45)	0.6189
Dyslipidemia	Yes vs no	1.06 (0.49–2.17)	0.8853	0.42 (0.21–0.86) ^*	0.0176	0.87 (0.34–2.70)	0.7963
Impaired Glucose Tolerance	Yes vs no	1.27 (0.88–1.85)	0.1943	1.65 (1.12–2.48) ^*	0.0115	1.48 (0.80–2.95)	0.2211
Age	over 65 vs under 65	2.98 (2.16–4.11) ^{* * *}	<0.0001	5.76 (4.10–8.16) ^{* * *}	<0.0001	4.72 (2.47–9.69) ^{* * *}	<0.0001
Sex	Women vs men	1.32 (0.92–1.90)	0.1342	1.02 (0.70–1.48)	0.9198	0.95 (0.56–1.66)	0.8691
Regional difference	Mountainous town vs seacoast town	1.75 (1.13–2.78) ^*	0.012	1.20 (0.77–1.89)	0.4353	0.14 (0.07–0.27) ^{* * *}	<0.0001
Smoking habit	Yes vs no	0.88 (0.54–1.44)	0.6002	0.90 (0.54–1.49)	0.6707	0.56 (0.29–1.12)	0.0984
Alcohol consumption	Yes vs no	0.94 (0.67–1.33)	0.7332	0.96 (0.67–1.37)	0.8332	0.92 (0.55–1.55)	0.7456

Multivariable logistic regression analysis was performed to determine the association of OW, HT, DL, and IGT with DD. The DD in the cervical, thoracic, or lumbar region was separately served as an objective variable. DD = disc degeneration, OW = Overweight, HT = Hypertension, DL = Dyslipidemia, IGT = Impaired Glucose Tolerance. Overweight was diagnosed as BMI ≥ 25, Hypertension was diagnosed as systolic BP ≥ 130 mm Hg and/or diastolic BP ≥ 85 mm Hg, DL was diagnosed as serum HDL-C level < 40 mg/dl, Impaired Glucose Intolerance was diagnosed as serum HbA1c level ≥ 5.5%

OR = odds ratio, 95% CI = 95% confidence interval

*p value < 0.001

***p value < 0.0001