FROM:
Arch Phys Med Rehabil 2025 (Feb 14):S0003-9993(25)00497-6 ~ FULL TEXT
Brian R. Anderson, DC, PhD Todd A. MacKenzie, PhD,
Leah M. Grout, PhD, MPH, James M. Whedon, DC, MS
Palmer Center for Chiropractic Research,
Palmer College of Chiropractic,
Davenport, IA.
Objective: To evaluate longitudinal cost outcomes of initial treatment strategies for new neck pain (NP) episodes among Medicare beneficiaries.
Design: Retrospective cohort study using Medicare Part A, B, and D claims data.
Participants: Medicare beneficiaries aged 65-99 years, continuously enrolled in Parts A, B, and D from 2018 to 2021, who experienced a new NP episode in 2019.
Interventions: Three cohorts were developed based on the index visit provider:
chiropractic (spinal manipulative therapy [SMT]),
primary care with prescription analgesics (PCP [+A]), and
primary care without analgesics (PCP [A], reference group).
Main outcome measures: Medicare allowed costs for total and NP-related claims (Parts A and B), and medication claims (Part D) over 24 months from the index visit.
Results: Among 291,604 older adults with NP, most were White women with few comorbidities. Compared to PCP (A), the SMT cohort had 6% (cost ratio, 0.94; 95% CI, 0.930.95) lower total Medicare Part A costs, whereas the PCP (+A) cohort showed no difference. For NP-related Part A claims, PCP (+A) had 7% (0.93; 95% CI, 0.880.98) lower costs, whereas SMT showed no difference. The SMT cohort had 6% (0.94; 95% CI, 0.940.95) lower total Medicare Part B costs and 36% (0.64; 95% CI, 0.640.65) lower NP-related costs, whereas PCP (+A) had 2% (1.02; 95% CI, 1.011.02) higher total costs. The SMT had 2% (0.98; 95% CI, 0.980.99) lower nonanalgesic and 13% (0.87; 95% CI, 0.870.88) lower analgesic Part D costs; the PCP (+A) had 13% (1.13; 95% CI, 1.121.14) higher nonanalgesic but 14% (0.86; 95% CI, 0.860.87) lower analgesic costs. Propensity weighting balanced covariates among cohorts.
Conclusions: For older adults with new NP episodes, initial SMT was associated with lower health care costs, particularly for Part A total and NP-related claims, with a less pronounced effect on Part B and D claims than PCP-related strategies. These findings suggest potential for health care savings based on the initial treatment choice.
Keywords: Analgesics; Cervical pain; Cost analysis; Medicare; Primary care physicians; Rehabilitation; Spinal manipulation.
From the FULL TEXT Article:
Background
Neck pain (NP) and low back pain represent the third largest
health care expenditure category among 155 conditions. These
conditions account for nearly $135 billion in annual health care
costs, with Medicare and Medicaid covering about one-third of
the total. [1] A 6fold increase in spending relative to prevalence highlights a growing reliance on high-cost interventions, such as spinal injections and fusion surgeries. [13]
A recent review of NP treatment guidelines indicates a consensus supporting the use of manipulation or mobilization, with
about half also recommending medications either alone or in
combination with other therapies. [4] A systematic review comparing spine-related treatment costs between chiropractic care
and medical management found that of 44 studies, only one
focused on NP, specifically involving younger, commercially
insured individuals. [5] This study aims to address a crucial gap by examining long-term costs associated with different initial care strategies for new NP episodes among Medicare beneficiaries
Methods
We conducted a retrospective cohort study using Medicare claims
from beneficiaries aged 6599 years who were continuously
enrolled in Parts A, B, and D from 2018 to 2021 and experienced
a new episode of NP in 2019. A comprehensive set of ICD-10
diagnosis codes was used to identify NP episodes (supplemental appendix S1, available online only at http://www.archives-pmr.org/); individuals with cancer diagnoses, skilled nursing facility claims, or hospice care use in 2018 were excluded to avoid opioid medication confounding.
New NP episodes were defined as at least one paid claim with a
primary NP diagnosis after a 90day period without such claims.
The episode ended when another 90day period passed without a
primary NP visit. If multiple episodes occurred, only the first was analyzed. Each participant had a standardized 24month follow-up from the index visit. Incident and prevalent NP cases were not distinguished because of the inability to rule out prior NP.
We obtained demographic characteristics from the Beneficiary
Summary File, whereas chronic conditions and Charlson Comorbidity Index scores were identified through Part A and B claims from 2018. Because of low frequencies, the 7 race codes were consolidated into 4 categories. Dual Medicare/Medicaid enrolment and Part D subsidy highly correlated low-income markers were combined; beneficiaries with either were classified as lowincome. Chronic conditions were selected based on literature linking them to opioid prescriptions. [6]
Based on the index visit provider in 2019, we identified 3
cohorts:
(1) SMT: beneficiaries whose index visit was with a chiropractor (specialty code 35);
(2) primary care physician without analgesics (PCP [A]): beneficiaries who visited a primary care physician (codes 01, 08, or 11) without a Part D claim for an analgesic medication within 7 days; and
(3) primary care physician with analgesics (PCP [+A]): beneficiaries who visited a PCP and had at least one Part D claim for an analgesic medication within 7 days.
Analgesic medications included nonsteroidal anti-inflammatory drugs and opioids; all other medications were classified as nonanalgesics. Medicare guidelines restrict reimbursement for chiropractic services to only SMT, making chiropractic care synonymous with SMT in Medicare claims data. [7]
We assessed total and NP-related Medicare allowed costs per beneficiary over a 24month period starting with the index visit, categorized by treatment cohort and Medicare program (Parts A, B, and D). To adjust for variations across cohorts and large standard deviations, we calculated weighted mean costs and standard deviations using the inverse probability of treatment weighting.
Table 1 page 4
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The propensity scores were computed using multinomial logistic
regression based on covariates in Table 1. These scores were applied as the inverse probability of treatment weights in generalized linear models (PROC GENMOD) using a g distribution with a log link. Separate models were conducted for Medicare Parts A, B, and D. All covariates were included in the weighted models for a doubly robust estimation of allowed cost ratios for Medicare Parts A and B (total and NP-related claims) and Part D (nonanalgesic and analgesic claims). Our study adhered to the STROBE guidelines for cohort studies (see supplemental appendix S1), and protocols were approved by the institutional review board.
Results
Among the 291,604 older adults with NP, the majority were White
women, with most having 0 or 1 comorbidity. The SMT cohort
constituted 63% of index visits and was characterized by a predominantly White demographic, a lower proportion of lowincome beneficiaries, and overall better health. This cohort had
fewer chronic conditions and a higher number of individuals with
a Charlson Comorbidity Index score of 0 than other cohorts (all
differences were statistically significant at P<.05). The PCP (A) cohort accounted for 29% of index visits, whereas the PCP (+A) cohort represented 8% (table 1). Propensity weighting effectively balanced covariates, as indicated by the standard mean difference values of less than 0.1 across all covariate comparisons, thereby minimizing bias from nonrandom treatment selection (see supplemental appendix S1).
Regarding Part A claims, the SMT cohort demonstrated 6%
lower total costs (cost ratio, 0.94; 95% CI, 0.930.95), whereas the PCP (+A) cohort did not show a significant difference than the PCP (A) cohort. For NP-related Part A claims, the results were reversed: the PCP (+A) cohort had 7% lower costs (cost ratio, 0.93; 95% CI, 0.880.98), whereas the SMT cohort did not show a significant difference.
For Medicare Part B claims, the SMT cohort again demonstrated
6% lower total costs (cost ratio, 0.94; 95% CI, 0.940.95), whereas the PCP (+A) cohort showed 2% higher costs than PCP (A)
cohort. Regarding NP-related Part B claims, the SMT cohort was
associated with a 36% cost savings (cost ratio, 0.64; 95% CI, 0.640.65), whereas the PCP (+A) cohort had a 1% increase in costs.
Table 2 page 5
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When evaluating Medicare Part D allowed cost, the SMT cohort exhibited 2% lower total costs for nonanalgesic medications (cost ratio, 0.98; 95% CI, 0.980.99), whereas the PCP (+A) cohort demonstrated 13% higher cost (cost ratio, 1.13; 95% CI, 1.121.13). The SMT cohort exhibited 13% lower total costs for analgesic medications (cost ratio, 0.87; 95% CI, 0.870.88). Paradoxically, the PCP (+A) cohort also exhibited lower total analgesic costs (cost ratio, 0.86; 95% CI, 0.860.87) (Table 2).
Discussion
This study is among the first to evaluate longitudinal costs associated with different NP-related treatment patterns. Although several cost differences were statistically significant, their clinical and economic relevance varied substantially. The most notable absolute cost differences were observed in Part A, where SMT was associated with approximately $435 lower total costs and $282 lower NP-specific costs than PCP (A). In contrast, the differences in Part B were relatively minor, amounting to approximately $5 and $20 for total and NP-specific claims, respectively, within the same comparison groups. Similarly, Part D showed minimal variations of approximately $7 and $1 for analgesic and nonanalgesic categories, respectively, suggesting limited economic implications despite statistical significance.
The discrepancies between cost ratios and weighted mean costs
in Parts A and D analyses highlight the methodological nuances of health care cost data. For Part A NP-related claims, the cost ratio indicates comparable costs between SMT and PCP (A), but the weighted means reveal a striking disparity ($37.8 vs $319.9), underscoring the skewed distribution of inpatient care, as evidenced by very large standard deviations.
Conversely, outpatient (Part B) costs appear more consistent,
as evidenced by smaller standard deviations. For Part D nonanalgesics, the cost ratio suggests 2% lower costs for SMT, whereas the weighted means indicate slightly higher costs ($20.3 vs $19.5). This apparent discrepancy likely reflects how these 2 measures (geometric versus arithmetic means) respond differently
to the underlying cost distribution. [8] These distinctions emphasize the need to consider both metrics to fully understand cost comparisons.
Demographic characteristics and high utilization of SMT align
with findings from similar studies evaluating NP treatment among
Medicare beneficiaries. [9, 10] Given the scarcity of directly comparable research on NP-related cost outcomes, we refer to a systematic review comparing the cost-effectiveness of chiropractic care versus medical management for musculoskeletal pain. [5] This review, encompassing 44 studies, revealed that 6 of 8 studies evaluating per-episode costs found chiropractic care to be more economical. In addition, both studies examining long-term health care costs favored chiropractic care. Cost reductions in the chiropractic group were attributed to decreased utilization of imaging studies, prescription opioids, surgeries, hospitalizations, injections, specialist visits, and emergency department visits.
Interestingly, our study observed reduced analgesic costs in the
PCP (+A) cohort. Although the exact reason for this is unclear, it may be attributed to effective early pain management, potentially mitigating the need for long-term prescription analgesic use.
Study limitations
Several limitations should be acknowledged. First, our dataset did not include Medicare Advantage enrollees. Second, insurance claims data lack information on the use of nonprescription medications. Third, NP severity and disability cannot be determined from insurance claims. Fourth, although we implemented a 90day clean window without an NP-related visit, the previous episodes or ongoing care for persisting NP cannot be ruled out. Finally, despite robust methodological strategies, observational data preclude the identification and elimination of all potential confounders, including treatment selection bias. Future research should investigate the underlying mechanisms driving the cost disparities identified in this study, as well as explore additional nonsurgical
interventions, such as physical therapy.
Conclusions
For older adults with new NP episodes, the initial SMT is associated with lower health care costs, particularly for Part A total and NP-related claims, with a less pronounced effect on Part B and D claims than PCP-related strategies. These results underscore the potential for health care cost savings based on the initial treatment approaches.
Corresponding author
Brian R. Anderson, DC, PhD, Palmer Center for Chiropractic
Research, Palmer College of Chiropractic, 741 Brady St, Davenport, IA 52803. E-mail address: Brian.anderson@palmer.edu
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