| Author, Year, Followup,a Pain Duration, Study Quality | Intervention | Population | Function and Pain Outcomes | Other Outcomes |
|---|---|---|---|---|
Banth, 2015194 1 month Duration of pain: ≥6 months Poor | A. Mindfulness-based stress reduction (n=24) 8 1.5-hour sessions over 8 weeks B. Usual care (n=24) 48 of 88 patients were analyzed, n for each group NR | A vs. B (NR) Age: 40 years Female: 100% Baseline function: NR McGill Pain questionnaire total score (0-45): 26.08 vs. 26.71 | A vs. B 1 month McGill Pain questionnaire total score (0-45): 13.58 vs. 23.60 | A vs. B 1 month SF-12 Mental component (0-100): 31.54 (4.3) vs. 24.29 (5.2) SF-12 Physical component (0-100): 28.08 (4.2) vs. 21.08 (3.3) |
Cherkin, 2016104 Herman, 2017196 Cherkin, 2017195 (2 year data from Cherkin, 2016) 22 months Duration of pain: >3 months (>1 year in 80% of patients) Fair | A. Mindfulness-based stress reduction (n=116), 8 2-hour sessions over 8 weeks (optional 6 hour retreat) B. Usual care (n=113) | A vs. B 50 vs. 49 years Female: 61% vs. 77% Baseline modified RDQ (0-23): 11.8 vs. 10.9 Baseline pain bothersomeness (0-10): 6.1 vs. 6.0 | A vs. B 4.5 months Modified RDQ (0-23), mean change from baseline: −4.33 (95% CI −5.16 to −3.51) vs. −2.96 (95% CI −3.79 to −2.14) Pain bothersomeness (0-10), mean change from baseline: −1.48 (95% CI −1.86 to −1.11) vs. −0.84 (95% CI −1.21 to −0.46) ≥30% improvement in RDQ: 60.5% (95% CI 52.0 to 70.3) vs. 44.1% (95% CI 35.9to 54.2) ≥30% improvement in pain bothersomeness: 43.6% (95% CI 35.6 to 53.3) vs. 26.6% (95% CI 19.8 to 35.9) 10 months Modified RDQ, mean change from baseline:−5.3 (95% CI −6.16to −4.43) vs. −4.78 (95% CI −5.67to −3.89) vs. −3.43 (95% CI −4.33 to −2.52) Pain bothersomeness, mean change from baseline: −1.95 (95% CI −2.32 to −1.59) vs. −1.10 (95% CI −1.48 to −0.71) ≥30% improvement in RDQ: 68.6% (95% CI 60.3 to 78.1) vs. 48.6% (95% CI 40.3 to 58.6) ≥30% improvement in pain bothersomeness: 48.5% (95% CI 40.3 to 58.3) vs. 31.0% (95% CI 23.8 to 40.3) 22 months Modified RDQ (0-23): −4.09 (95% CI−5.08 to −3.10) vs. −2.74 (95% CI−3.81to −1.68) ≥30% improvement in modified RDQ: 55.4% (95% CI 46.9 to 65.5) vs. 42.05% (95% CI 33.8 to 52.2) Pain bothersomeness: −1.57 (95% CI −1.97 to −1.17) vs. −1.25 (95% CI −1.69 to −0.81 ≥30% improvement in pain bothersomeness: 41.2% (95% CI 33.2 to 51.0) vs. 31.1% (95% CI 23.9 to 40.5) | A vs. B 4.5 months SF-12 MCS, mean change from baseline (0-100): 0.45 (95% CI −0.85 to 1.76) vs. 2.13 (95% CI 0.86 to 3.40) vs. −1.11 (95% CI −2.39 to 0.17) SF-12 PCS, mean change from baseline (0-100): 3.58 (95% CI 2.15 to 5.01) vs. 3.27 (95% CI 2.09 to 4.44) Used medications for LBP: 43.4% (95% CI 35.9to 52.6) vs. 54.2 (95% CI 46.2 to 63.6) 10 months SF-12 MCS, mean change from baseline: 2.01 (95% CI 0.74 to 3.28) vs. 0.75 (95% CI −0.58 to 2.08) SF-12 PCS, mean change from baseline: 3.87 (95% CI 2.55 to 5.19) vs. 2.93 (95% CI 1.70 to 4.16) Used medications for LBP: 46.8% (95% CI 39.2 to 55.9) vs. 52.9% (95% CI 45.1 to 62.0) Total costs: $5,580 (95% CI $3,465, $8,343) vs. $6,304 (95% CI $4,193, $9,805) |
Morone, 2009198 4 months Duration of pain: Mean 9.4 to 11 years Fair | A. Mindfulness-based stress reduction (n=16), 8 1.5-hour sessions over 8 weeks B. Attention control (education) (n=19) | A vs. B Age 78 vs. 73 years Female: 69% vs. 58% Baseline RDQ: 8.8 vs. 11.3 Baseline McGill Pain Questionnaire Current Pain (0-10): 2.9 vs. 4.4 | A vs. B 4 months RDQ: 7.6 (95% CI 6.2 to 8.7) vs. 10.0 (95% CI 8.7 to 11.2) McGill Pain Questionnaire Total Score (0-45): 12.4 (95% CI 10.4 to 14.6) vs. 12.0 (95% CI 10.2 to 13.7) McGill Pain Questionnaire Current Pain (0-10): 2.3 (95% CI 1.6 to 2.8) vs. 3.7 (95% CI 3.1 to 4.3) | A vs. B 4 months SF-36 Pain Score (10-62): 41.4 (95% CI 39.8 to 43.1) vs. 40.5 (95% CI 38.7 to 42.2) |
Morone, 2016197 4.5 months Duration of pain: Mean 11 years Fair | A. Mindfulness-based stress reduction (n=140), 8 1.5-hour sessions over 8 weeks, with 6 monthly booster sessions B. Control, (health education) (n=142) | A vs. B Age: 75 vs. 74 years Female: 66% vs. 66% Baseline RDQ (0-24): 15.6 vs. 15.4 Baseline Pain (0-20 NRS): 11.0 vs. 10.5 | A vs. B 4.5 months RDQ: 12.2 vs. 12.6, adjusted difference −0.4 (95% CI −1.5 to 0.7) RDQ improved ≥2.5 points: 49.2% (58/117) vs. 48.9% (66/135), p=0.97 Pain (0-20 NRS): 9.5 vs. 10.6, adjusted difference −1.1 (95% CI −2.2 to −0.01) Pain improved ≥30%: 36.7% (43/117) vs. 26.7% (36/135), p=0.09 | A vs. B 4.5 months SF-36 Global Health Composite (9-67): 42.4 vs. 41.2, adjusted difference 0.2 (95% CI −1.9 to 2.4) SF-36 Physical Health Composite (20 to 65): 41.2 vs. 41.2, adjusted difference −0.1 (95% CI −1.9 to 1.8) |
Zgierska, 2016199 4.5 months Duration of pain: Mean 14 years Poor | A. Mindfulness-based stress reduction (n=21): 8 weekly 2 hour group sessions plus 30 minutes/day, 6 days/week of at home practice B. Usual care (n=14) | Overall Age: 51.8 years Female: 80% Baseline ODI (0-100): 68.1 vs. 64.5 Baseline Brief Pain Inventory pain intensity (0-10): 6.3 vs. 4.9 Baseline Opioid dose 166.9 vs. 120.3 | A vs. B 4.5 months ODI (0-100): −5.0 (95% CI 9.7 to 0.2) vs. 1.6 (95% CI −4.3 to 7.4) Brief Pain Inventory pain intensity: −0.5 (95% CI −1.1 to 0.02) vs. 0.5 (95% CI 0.2 to 1.2) | A vs. B 4.5 months Opioid dose (mg morphine equivalents): −10.1 (95% CI −35.5 to 15.2) vs. −0.2 (95% CI −31.4 to 30.9) |
Unless otherwise noted, followup time is calculated from the end of the treatment period
From: Results
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