The Impact of Individualized Complementary and
Integrative Health Interventions Provided in
Clinical Settings on Quality of Life: A
Systematic Review of Practice-Based Research

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:    Frankp@chiro.org

FROM:   J Integr Complement Med 2022 (Aug); 28 (8): 618–640 ~ FULL TEXT

Natalie L. Dyer, Jessica Surdam, Roshini Srinivasan, Ankita Agarwal, and Jeffery A. Dusek

Connor Whole Health,
University Hospitals,
Cleveland, OH, USA.

Duke University School of Medicine,
Durham, NC, USA.

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Background:   The goal of this systematic review was to evaluate the impact of individualized complementary and integrative health (CIH) interventions on quality-of-life outcomes as collected in CIH outpatient clinics.

Methods:   A systematic review was conducted using PubMed, OVID, Cochrane, Web of Science, Scopus, and Embase through December 2020. Inclusion criteria were as follows: individualized CIH treatment, longitudinal effectiveness design, patient-reported outcomes, outpatient CIH clinic setting, participants aged ≥18 years, sample size of ≥25, and English full text. The study was listed in the PROSPERO database (CRD42020159193), and PRISMA guidelines were used. The variables extracted from articles focused on study details/demographics, CIH intervention characteristics, and outcome characteristics.

Results:   The literature search yielded 3316 records with 264 assessed for full-text review. Of these, 19 studies (including ~14,002 patients) were specific to quality of life (or well-being) as a main outcome. Most studies included were multidisciplinary studies (n = 12), followed by acupuncture (n = 4), chiropractic (n = 3), and massage or reflexology (n = 1). The short-form group of questionnaires (SF-12, SF-36, SF-8) were the most used quality-of-life/well-being questionnaire, comprising 37% of studies (n = 7), and the Patient Reported Outcomes Measurement Information System (PROMIS) measures comprised 21% (n = 4). Both questionnaires are normed to U.S. population, allowing for comparison. The average improvement across the comparable SF and PROMIS measures for Physical Health was 6% (range 2%-20%) and for Mental Health was 5% (range 1%-11%), demonstrating clinical significance. Improvements in the observational studies are comparable to improvements reported from randomized controlled trials.

Conclusions:   Results from this systematic review indicate that CIH therapies largely have positive effects on health-related quality of life and well-being for various patient populations seen in CIH clinical settings. Direct comparisons across studies were limited due to the variability in study design and incomplete reporting in some of the publications. Suggestions for improving the design and reporting for future practice-based research are provided.

Keywords:   cancer; complementary and integrative health; integrative medicine; pain; practice-based research; quality of life; systematic review; well-being.

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