Natural Medicine and Nutritional Therapy as an Alternative Treatment in Systemic Lupus Erythematosus Alternative Medicine Review 2001 (Oct);   6 (5):   460–471 ~ FULL TEXT Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder without a known cure. Conventional medicine typically approaches the disease with a treatment plan that includes the use of corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDS), antimalarial drugs, and chemotherapeutic agents. The results vary and safety is questionable. Conservative treatment methods, such as the use of vitamins, minerals, and fatty acids, have been shown to have an impact on the activity of the disease.
	Omega-3 Fatty Acids in the Prevention-management of Cardiovascular Disease Can J Physiol Pharmacol 1997 (Mar);   75 (3):   234–239 Fish oil has been shown to reduce ventricular arrhythmias and to be more beneficial than currently used pharmacologic agents. The dose, duration, and mechanisms involved in the prevention and management of cardiovascular disease following omega-3 fatty acid ingestion or supplementation need to be investigated by double blind controlled clinical trials.
	Magnesium Taurate and Fish Oil for Prevention of Migraine Med Hypotheses 1996 (Dec);   47 (6):   461–466 Although many drugs have value for migraine prophylaxis, the two nutritional measures suggested here may have particular merit owing to the versatility of their actions, their safety and lack of side-effects and their long-term favorable impact on vascular health.
	Long-term Effects of Eicosapentaenoic Acid (EPA) on Diabetic Peripheral Neuropathy and Serum Lipids in Patients with Type II Diabetes J Diabetes Complications 1996 (Sep);   10 (5):   280–287 The results of this study suggest that EPA-E has significant beneficial effects on diabetic neuropathy and serum lipids as well as other diabetic complications such as nephropathy and macroangiopathy.
	Effects of Interaction of RRR-alpha-tocopheryl Acetate and Fish Oil on Low-density-lipoprotein Oxidation in Postmenopausal Women with and without Hormone-replacement Therapy Am J Clin Nutr 1996 (Feb);   63 (2):   184–193 Supplements as low as 100 mg alpha-tocopheryl acetate/d increase the resistance of LDL to oxidation when fish oil supplements are used. HRT and fish oil supplements may independently affect LDL oxidative susceptibility.
	Beneficial Effect of Eicosapentaenoic (EPA) and Docosahexaenoic Acids in the Management of Systemic Lupus Erythematosus (SLE) and its Relationship to the Cytokine Network Prostaglandins Leukot Essent Fatty Acids 1994 (Sep);   51 (3):   207–213 Oral supplementation of EPA and DHA induced prolonged remission of SLE in 10 consecutive patients without any side-effects. These results suggest that n-3 fatty acids, EPA and DHA, are useful in the management of SLE and possibly, other similar collagen vascular diseases.
	Effects of Dietary Fish Oil Lipids on Allergic and Inflammatory Diseases Allergy Proc 1991 (Sep);   12 (5):   299–303 This suggests that EPA has anti-inflammatory potential. Clinical trials in rheumatoid arthritis, psoriasis, atopic dermatitis, and bronchial asthma have shown beneficial effects.
	A Fish Oil Diet Rich in Eicosapentaenoic Acid (EPA) Reduces Cyclooxygenase Metabolites, and Suppresses Lupus in MRL-lpr Mice J Immunol 1985;   134 (3):   1914–1919 We suggest that this change in endogenous cyclooxygenase metabolite synthesis directly suppresses immunologic and/or inflammatory mediators of murine lupus.